In 2018 Natera paid a $11 million fine to the department over allegations of improper billing and sales of Panorama to federal Healthcare services between the years of 2013 to 2016. The Signatera CLIA test was introduced for clinical use in 2019. That same year, Natera introduced the Signatera molecular residual disease (MRD) test for research use only. In 2017, Natera launched the Vistara single-gene NIPT. The shares trade on the Nasdaq Global Select Market under the symbol "NTRA." In July 2015, Natera conducted an initial public offering of common stock at a price of $18.00 per share. The following year, 2013, Natera launched the Panorama non-invasive prenatal test (NIPT). Natera's advanced carrier screening test, Horizon, launched in 2012. In 2010, the company introduced the Anora miscarriage (POC) test. Natera launched its first product, the Spectrum preimplantation genetic test, in 2009. Natera (previously Gene Security Network) was founded by Matthew Rabinowitz and Jonathan Sheena in 2004. Natera operates CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in San Carlos, California and Austin, Texas. ![]() ![]() Natera’s proprietary technology combines novel molecular biology techniques with a suite of bioinformatics software that allows detection down to a single molecule in a tube of blood. is a clinical genetic testing company based in Austin, Texas that specializes in non-invasive, cell-free DNA (cfDNA) testing technology, with a focus on women’s health, cancer, and organ health.
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![]() ![]() Despite the title, it covers events from both the first and the second film in the trilogy. 3 less than the PS2 original, they concluded that GameCube was the best version.Electronic Arts' first game based on the Lord of the Rings movies is an action game with classic beat'em up-style gameplay. The title was one of the top selling console titles of 20 and was widely praised for its seamless transitions from actual film footage to interactive game play.IGN, rated the PS2, Xbox and GameCube versions 8.3, 7.6 and 8.0, respectively, they noted the vivid graphics, the well-implemented beat em' up gameplay, the RPG-style elements and the transition from FMV to in-engine cutscenes, in terms of flaws, they noted that the game was actually hard, that the Xbox version was the same as PS2 and there were only 4 characters to choose, but in conclusion was lasting due to its extras and leveling up. The Lord of the Rings: The Two Towers is a 2002 cross-platform video game based on Peter Jackson's New Line Cinema films The Lord of the Rings: The Fellowship of the Ring and The Lord of the Rings: The Two Towers. The title was one of the top selling console titles of 20 Verified purchase: Yes | Condition: Pre-owned Overall, I would give it a rating of 4/5. It's a wonderful, nostalgic experience to go back and play this game once more, such as I did when I was a little kid. So to recap this is a great game for anyone who had a blast with the Peter Jackson film and who still has a PS2 to run this bad boy on. The game also includes various behind-the-scenes works, and features some of the movie stars and their personal experiences with the Two Towers game, which I thought was pretty interesting, and also kind of hilarious. Since these cut scenes are involved, the game largely follows the portrayal of the series exactly as it was in the Peter Jackson film, with the eventual option of more character choices once you have completed the game. The game takes scenes directly from the Two Towers movie produced by Peter Jackson and has them morph into the actual game events. While the gameplay is very standard for the PS2 you hack and slash you way through various middle-earth themed enemies from orcs and uruk-hai to the deathly Nazgul, utilizing button mashing combos along the way to maximize the damage dealt it is a great game and has that iconic LOTR charm to it. I remember this being one of the first games I had as a kid. This game is a classic PS2 adventure for any fan of the Lord of the Rings series, both book and/or movie trilogy. The Two Towers: A Great Game for a Great Movie ![]() The disc also offers unlockable extras, such as interviews with some members of the film's cast, extra characters, and sneak peaks of the second movie in the trilogy. ![]() Throughout these worlds, players will encounter familiar NPCs and even occasionally fight alongside the likes of Gandalf. Twelve missions make up the bulk of the gameplay, with additional branching paths added to the main mission structure at various junctures. At the conclusion of each level, players can use these points to increase character attributes or purchase new combination maneuvers. These combination attacks reward players with varying grades the more frequent and lavish the combo, the better the grade and the more points earned. Far from helpless, players are able to parry blows and execute melee (quick and fierce) and ranged attacks, as well as a number of combination attacks. In each of these areas, players are beset by hordes of enemy orcs and other such assailants, in addition to fearsome boss creatures. Players will revisit such familiar locales as Fangorn Forest and the Mines of Moria. Then, embark on a quest that spans a multitude of levels. Players choose from three warrior characters, patterned after their onscreen personas: Legolas the Elf, Aragorn the Ranger, or Gimli the Dwarf. The story is told through footage from the movie that slowly melds to in-game cinematic screens, all explaining the origin of The Ring and those who covet it. The game is inspired by the battle scenes found therein. The Lord of the Rings: The Two Towers is a beat-'em-up action title that follows events from the first two films in the movie trilogy, which is based on the novels of J.R.R. ![]() ![]() Select "Configure" -> "Disable Hardware Acceleration (OpenGL, OpenCL)".Start LibreOffice in Safe Mode (open "LibreOffice (Safe Mode)" in the Windows start menu or run libreoffice -safe-mode in the Linux terminal).If LibreOffice crashes immediately on startup, it will not be possible to open the Options dialog and disable OpenGL there, so you have two options: LibreOffice comes with OpenGL rendering enabled by default and this configuration might cause problems with certain combinations of graphics hardware and their drivers, which can lead to crashes. Open the viewer and click on the Report tab in the tab bar. On 64-bit macOS 10.6 or higher, download and install OpenGL Extensions Viewer from the Mac App Store. Details of which OpenGL versions are supported and the percentage of that support will be listed along with summary details of your graphics card and its OpenGL support, which will look like this. Open the viewer through the Start menu and click on the Report link in the Task pane on the left. ![]() On Windows XP or higher, download and install the OpenGL Extensions Viewer. When reporting bugs related to OpenGL, it is useful to include your system's graphics card information. Go to Tools ▸ Options ▸ LibreOffice ▸ View ( LibreOffice ▸ Preferences ▸ LibreOffice ▸ View on macOS) and on the right side, check/uncheck Use hardware acceleration Get your computer's OpenGL information LibreOffice can be run with old versions of OpenGL, but the recommended minimum OpenGL version that will perform well is version 2.1, while the recommended OpenGL version is 3.3 or higher. OpenGL support in LibreOffice has been in constant improvement since version 4.3 (thanks to work by Markus Mohrhard, Tomaž Vajngerl, Zolnai Tamás, and others) and with that, users may experience crashes in LibreOffice, so we are providing the following information to assist them with such crashes. To revive discussion, seek broader input via a forum such as one of our mailing lists. This page was marked as inactive and is retained for historical reference.Įither the page is no longer relevant or consensus on its purpose has become unclear. FeaturesĬalibre is a powerful and easy to use e-book manager. Update automatically or install from the portable app store in the Platform. And it's open source and completely free. It's in Format so it can easily integrate with the Platform. calibre is an ebook manager, converter, and viewer with support for a variety of formats and devices. Some of the alternatives to Calibre include: Google Books, Project Gutenberg, iBooks and more.Ĭalibre is a good library management tool and while it may suit budding e-book collectors, advanced users who need a more comprehensive set of functions in regards to perform complex actions for their e-book collections might find Calibre a little disappointing.A new version of calibre Portable has been released by. As a result, you don’t know if a specific book is on your tablet, smartphone or PC. Another downside that is present in Calibre is its inability of keeping track of where your e-books are stored. Any e-books stored in your e-reader's archives cannot be seen by the directory. Some gaps in the functionality of Calibre can be found because not everything works smooth. Other features of Caliber include the ability to add books from different sources, convert various e-book formats to the one your e-reader uses and organize info about the authors. Once a book is selected, the cover art, a list of formats in which the e-book is available, tags (either downloaded or added by the user) and the file path on your PC or e-reader where the work is stored will be available on the right side of the main window. ![]() All of the books of a specific author can be easily found just by clicking on its name. The left side of the main windows offers the following categories: Formats, Authors, Publishers, Ratings, News and Tags. Any of the data fields Calibre fills in can be organized, categorized, annotated, searched and rated. Once scanned, these files are introduced into Caliber’s main directory. Calibre is a powerful library management tool that works by surveying all of the e-books as well as other relevant files from your hard drive or r-reader. In a nutshell, cataloguing your e-book collection has never been so easy. ![]() Novice users will certainly appreciate the interface of Calibre as well as the strategic placement of the buttons and easy to navigate controls. The interface looks great, it is intuitive and the process of downloading your e-books from your desktop or hard drive to Calibre is a simple one. The professionally designed layout and easy-to-use command icons of the interface are a triumph. ![]() It doesn’t come bundled with adware, spyware or other programs and in terms of specs, you might want to know that Calibre supports all of the available versions of Windows. With a setup kit that measures around 40MB in size, you will be organizing your e-books in no time. ![]() Let’s analyze its features in this quick article and find out more about Calibre.Ĭalibre boasts a fast and smooth installation process that will certainly not pose any problems to you. Any electronic reading lover will appreciate this lightweight yet very useful tool. You need Calibre a tool that incorporates all the elements you need to organize and manage an e-book collection. But the management of your books is a mess. As a result, you have thousands of e-books waiting to be read. Dozens of e-book bestsellers were purchased by you in a heartbeat. That Kindle you’ve been dreaming about in the last months is finally in your hands. ˜… Winner of Best Ebook Management Tool in 20. " E-book library management application." Due is a smart application and able to meet your needs. The action of adding new items to Due is very basic, but with the smart input feature, adding reminders happens very quickly. This is one of the features that makes Due outstanding. Use it to create a reusable countdown reminder for all your tasks, from kitchen work to other work-based activities. ![]() And the syncing feature with iOS app will allow you to update anywhere.ĭue to many favorite iOS users, Due also received a lot of positive feedback because it is very easy to use on macOS.ĭue provides the ability to set up simple reminders with many customizations. You can even set reminders based on location in Doo when you come or leave. Like Later, Doo runs from the menu bar and is appreciated for its beautiful image. Create repeat reminders, add checklists on each reminder, customize times between times and set pre-presets for morning and evening to add reminders in a snap. DooĪs one of the most appealing reminders in the Mac App Store, Doo provides a simple experience combined with a calendar application to visualize what's coming soon.ĭoo provides a card-based interface with the ability to add open or day-based tasks. It is available on the menu bar for easy access and perfect for application beginners.ĭownload Later ($ 10 / 230,000 VND). Sync with Later iOS app and you can set a prompt only for Mac to appear on your computer during the next session. You can easily customize presets and save time by setting a specific due date and time. Scheduling a reminder to appear in the next 3 hours or tomorrow night is a perfect way to plan everything. Its unique approach allows you to draw reminders based on presets in real life. Later is a basic reminder application for iOS and Mac. With Todoist, you can track the number of tasks you have completed in the week and more.ĭownload Todoist (Free, available registration). Recurring reminders help you set up regular schedules for important activities.Įverything is organized as well as possible. This service packs all the features you expect with task managers, such as labels, filters, project management, and even inboxes to add unordered reminders.Īdding tasks and quick reminders is one of Todoist's favorite features. Todoist brings advanced productivity software and combines it with elegant design. ![]() If you want to go further with your reminders, consider Todoist. However, at present, Wunderlist is still advertised as one of the best task management tools. Although this application is still available, Microsoft is planning to stop providing Wunderlist to support the new Microsoft To-Do application. ![]() Placing a recurring reminder gives you all you need to set up routine-based activities. In the control panel, you can organize reminders into projects, providing you with basic organizational options. Wunderlist allows you to add due dates, files, comments, notes and tags to any reminder. One of the most famous task management applications, Wunderlist provides all the features to manage reminders. Clear allows you to synchronize with iCloud to link your iOS devices, so you can access your tasks from anywhere.ĭownload Clear ($ 10 / 230,000 VND). Gestures perfectly integrate with the trackpad or Magic Mouse, allowing you to swipe and connect to your tasks. The ability to organize tasks using this list view helps you not to be distracted when managing reminders on your Mac. ![]() Delivering a bright experience, this application allows users to customize lists by color and use gestures to quickly arrange them. Top reminder app to replace Apple Reminder for MacĬlear is one of the most useful Mac applications for people who like visual thinking. “Clients don’t have to move if the stylist has to move. ![]()
![]() ![]() The limit of snipers is a very welcome thought, as getting sniped over and over is not a fun prospect in any shooter. Only two people in the entire match will wield snipers, which are incredibly useful on the realistic maps covered in open fields. First up, we have the recon squad, who serve as the snipers creeping round and finding enemy hot points and potential flanking areas. Teams are split up between squads, and each serve a different but crucial purpose. This game doesn’t just level up your avatar, you’ll also be improving and learning as you play more and more matches. But eventually, you’ll start calling out enemy locations to your squad, and further still, recommending actions and tactics to help your squad contribute to your whole team. You’ll be a rookie at first, and may even stay quiet in the first few hours. Not only that, but it also adds to the fun of the core gameplay. This game goes far and above the “ping” system that has emerged from some team shooters, and your team will definitely benefit from you having a mic to play this game. When you open the game for the first time, you are informed that a microphone is strongly recommended to play Hell Let Loose, and I couldn’t agree more. This is no simple team deathmatch however the teams must utilize co-ordination and teamwork to help them fight on sprawling maps with fierce choke points and risky open fields. Up to 100 players are split into two teams, and must fight against each other to dominate the battlefield with artillery, infantry and armoured units. Hell Let Loose is an Online Multiplayer first-person shooter set in an extremely authentic WW2 era. But, if you’re simply excited to be immersed in the frantic WW2 mayhem surrounding you, then this may be the multiplayer shooter you’ve been looking for all your life. ![]() Does it make you feel frustrated and cheated? Probably not the game for you. How this unavoidable death makes you feel will pretty much determine if you’ll find enjoyment of this game. There’s absolutely nothing you or your squamates can do as the bomb hits the ground, and you see the respawn timer once more. Suddenly, you hear the unavoidable scream of an artillery rocket plummeting down towards you. After nearly getting hit by a swarm of bullets, you make it to cover, feeling relieved and excited to press ahead. The moment has come, as your squad waste no time and dart towards the objective, picking out enemy soldiers as they make haste towards the next cover. Bunkered down, you peek over cover but for a moment, revealing in front of you a massive field baron of cover, smoke grenades cover precious amounts of space to cover your advances. Your squad commander has issued you the task of capturing a control point, bullets are whizzing past you and planes are flying in the distance. So, you’ve respawned with a small crew around you, armed with the trusty M1 Garand. Hearing the distant scream of a Kar98 in Hell Let Loose never made my hair stand up the way guns can in Hunt: Showdown or Squad.Hell Let Loose. It's a cool effect on its own, but the noise doesn't carry well over a distance. The standard rifle sounds for all three playable factions (US, Germany, and Russia) sound more like bassy cannons than piercing screeches. I've heard lots of 'whizzes' and 'pops', but Hell Let Loose lacks the intimidating 'crack' you hear when a bullet breaks the sound barrier next to your face. Ironically, one of the most disappointing moments in Hell Let Loose is when bullets just barely miss me. Some of this comes down to the sound effects Black Matter chose for its WW2 arsenal of Kar98s, M1 Garands, and MP40s. ![]() No matter how much I mess with audio sliders, the game never gets loud enough for my liking. This is where Hell Let Loose kinda falls flat. When everything is tuned correctly, a gun should be so loud that I can't hear my teammate over the radio. Coming from dozens of hours in Squad, part of that game's immersion is letting the game overwhelm my ears with extremely loud guns, tank fire, and explosive ordnance. ![]() ***For best results, play Temple Run: Oz on iOS 6.***ĭon’t forget to see Oz the Great and Powerful on DVD and Blu-ray!īefore you download this experience, please consider that this app contains social media links to connect with others, in-app purchases that cost real money, push notifications to let you know when we have exciting updates like new content, as well as advertising for The Walt Disney Family of Companies and some third parties. Although there are also Disney versions of the game, including Temple Run: Brave and Temple Run: Oz, this 1 billion total does not include these additional. The player will fly in a hot air balloon, explore many game worlds, test his reaction to the.
![]() In those respects, The Shield’s pilot was par for the course. ![]() One reason that the events of pilots so rarely reverberate throughout a series’ run is that those first episodes are typically trial balloons floated by creators who haven’t mapped out where they want their shows to go and networks that may not be sold on their storytelling both are fumbling forward in the absence of feedback from a mass audience. “It opened up a lot of doors, and then shows came through and kicked them open even further,” Ryan says.įrom a plot standpoint, the pilot’s apparent prescience was partly engineered after the fact, as Ryan followed the threads that led from the episode’s stunning turnabout. Crowley’s unpredictable demise, and the ramifications that came from it, made America’s introduction to The Shield one of the most startling, momentous, and prescient pilots ever. It also altered TV history by blazing a trail on basic cable for the mature content and “ difficult men” who would dominate the decade’s indelible TV dramas. Leslie Knope crushes on Mark Brendanawicz and Andy Dwyer dates Ann Perkins on Parks and Recreation Coach costars instead of Winston on New Girl Xander’s close friend Jesse on Buffy is bitten by a vampire and, after Xander accidentally stakes him in the second episode, is never mentioned again.īut when Mackey murdered Crowley, a strike team member and would-be informant who’d agreed to blow the whistle on Mackey’s misdeeds, it set the long-term tone and course for a series that ran for 87 more episodes. To watch most pilots is to venture into a world where the series you remember hasn’t quite come together: where the writing is too cute or too caustic, the leads are still stuck in the wrong relationships, and actions lack consequences. It’s easier to summon examples of pilots that flopped so spectacularly that they never aired and led to recast roles, or that featured prominent characters who never returned, than it is to pick out pilots whose events resonated right through the series finale. Their job is to establish a premise and setting, introduce core characters, and convince spectators to come back next week (or, on a streaming service like The Shield’s current home, Hulu, to select “Next Episode”). ![]() “I don’t know that there was a pilot I can think of that had a specific incident that carried through to the finale the way that we were able to do with ours,” says series creator Shawn Ryan, who wrote the first and last episodes. Vic’s final fallouts with (and backstabs of) strike team members Shane (Walton Goggins) and Ronnie (David Rees Snell) Shane’s shocking murder-suicide Vic’s confrontation with a disgusted, accusing Claudette (CCH Pounder) an office-bound, bereft Vic’s silent, series-ending scene-all of those wrenching, Shakespearean moments and more traced their roots to the twist in the closing seconds of the series opener, which makes The Shield unusual, if not unique, among long-running series. Almost every meaningful moment in the last two episodes (including a finale that, like the legendarily well-concluded Breaking Bad’s, boasts the highest average IMDb user rating of any episode in the series) was set up by the Emmy-nominated pilot, which had aired six and a half years earlier-20 years ago this Saturday. What made the scene so special, aside from Michael Chiklis’s portrayal of a serial deceiver who’s forced to fess up to his (surviving) victims and to himself, is that the audience had been anticipating the moment when Mackey would come clean ever since the series started. After taking a twitchy minute to gather himself, he begins with the worst one: “I shot and killed detective Terry Crowley.” The duped, appalled ICE agent, who looks like she was expecting to send Mackey away with a finger wag and an instruction to say a few Our Fathers, asks, “You killed a police officer?” Mackey, both beaten and victorious, confirms, “I planned it. Immigration and Customs Enforcement in exchange for his help in apprehending a cartel enforcer, corrupt-cop protagonist Vic Mackey confesses his crimes into a tape recorder, unloading a long list of unpunished-and, as soon as he speaks, unpunishable-transgressions in a onetime, no-strings-attached absolution. Having wheedled an immunity deal out of U.S. In a sense, the series climaxes in a scene from the penultimate episode-not with a shootout, a car chase, or a dramatic interrogation, but with a man and a microphone in a nondescript room. TV drama doesn’t get more fraught, or more fulfilling, than the last two episodes of The Shield, the seven-season series about cops and criminals (and criminal cops) that aired on FX from 2002 to 2008. ![]() The 918 Spyder is not a car to simply jump in and blast off on first encounter. ![]() In real-world conditions, you should expect figures similar to those of more conventional combustion-engine powered sports cars.ĭriver’s side shot of the interior in the 918 spyder. However, it is achieved almost entirely in electric mode using a loophole in the European test procedure. Porsche is quick to highlight the official 78.4 mpg consumption. ![]() The truly remarkable thing about the new Porsche is while it delivers sledgehammer performance, its state-of-the-art gasoline-electric hybrid driveline allows it to record outstanding economy figures when driven at a leisurely pace. In electric mode it hits 93 mph before the gasoline engine fires. With a sophisticated aerodynamic package including a rear wing extending from the rear body work nearly 5 inches and providing three different downforce levels, the Spyder reaches a 214-mph top speed. When fitted with an optional Weissach performance package (lightweight components paring some 88 lbs from the curb weight), the Spyder hits 62 mph in 2.6 seconds, 124 mph in 7.2 seconds and 186 mph in 19.9 seconds. Nevertheless the official performance claims are spectacular. The battery comes with a seven-year guarantee and adds a significant 692 lbs to the 918 Spyder's 3,691-lb overall curb weight. Depending on the drive mode selected, the new Porsche can operate in front-, rear- or four-wheel drive modes.Ī 6.8 kWh lithium-ion battery mounted underneath the gasoline engine in back provides the energy used to run the electric motors. Power is delivered via both a fixed gear and seven-speed dual-clutch gearbox the former operates on the front axle to provide electric drive to the front wheels at speeds up to 165 mph, while the latter sits at the rear and drives the rear wheels with a combination of electric and gasoline-engine power. (Some perspective: The Carrera GT's 5.7-liter V10 gasoline engine, designed for a Le Mans challenger, kicks out 603 hp and less than half the 918 Spyder's torque, at 434 lb-ft.) Together, the three power sources produce 875 hp at 8,500 rpm and a thumping 944 lb-ft of torque. Two synchronous electric motors - one mounted up front and another at the rear - supplement the V8. Power for the new carbon-fiber Porsche is a mid-mounted 4.6-liter V8 gasoline engine based on the engine from the earlier RS Spyder race car. Up to now the GT was the fastest road-going Porsche model to ever lap the iconic German race circuit. There factory driver Marc Lieb established an official 6-minute, 57-second lap time, undercutting the Carrera GT by a stout 33 seconds. Since then the targa-roofed Porsche has undergone an intensive three-year development program culminating in a final validation test at the Nürburgring in early September. This is the fastest and most powerful road-going Porsche model yet-the ultra complex and breathtakingly expensive 918 Spyder.Ĭarrying on a celebrated line of racetrack-inspired limited-production specials, the 918 Spyder was first revealed as a concept at the 2010 Geneva motor show prior to receiving an official production greenlight later that year. |